The Increased Production Of Hydrogen Sulfide In Amyotrophic Lateral Sclerosis Is A Significant Risk Factor?

Author:Longone Patrizia, Davoli Alessandro, Ricciardo Rizzo Giada, Guatteo Ezia, Spalloni Alida, Greco Viviana, Urbani Andrea, Mercuri Nicola Biagio
Volume Info:Volume 1 Issue 2
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Article Information

Volume 1 Issue 2 , pages 35-37
Published Dec 2015

 

Longone Patrizia
Molecular Neurobiology Unit, Institute of Hospitalization and Scientific Care–Fondazione Santa Lucia, Rome

 

Longone Patrizia
Neurophysiopathology Unit, Department of System Medicine, University of Rome Tor Vergata, Rome

 

Ricciardo Rizzo Giada
Neurophysiopathology Unit, Department of System Medicine, University of Rome Tor Vergata, Rome

 

Guatteo Ezia
Experimental Neurology Unit, Institute of Hospitalization and Scientific Care–Fondazione Santa Lucia, Rome

 

Spalloni Alida
Molecular Neurobiology Unit, Institute of Hospitalization and Scientific Care–Fondazione Santa Lucia, Rome

 

Greco Viviana
Department of Experimental Medicine and Surgery, Department of System Medicine, University of Rome Tor Vergata, Rome

Proteomics and Metabonomics Unit, Institute of Hospitalization and Scientific Care–Fondazione Santa Lucia, Rome

 

Urbani Andrea
Department of Experimental Medicine and Surgery, Department of System Medicine, University of Rome Tor Vergata, Rome

Proteomics and Metabonomics Unit, Institute of Hospitalization and Scientific Care–Fondazione Santa Lucia, Rome

 

Mercuri Nicola Biagio
Neurophysiopathology Unit, Department of System Medicine, University of Rome Tor Vergata, Rome

Experimental Neurology Unit, Institute of Hospitalization and Scientific Care–Fondazione Santa Lucia, Rome

 

Corresponding Author: mercurin@med.uniroma2.it

Abstract:


Amyotrophic lateral sclerosis (ALS) is a motor neuron disease whose pathophysiological deficits causing impairment in motor function are largely unknown. Recently, our group has found significant high levels of H2S in the liquor of 37 ALS sporadic patients and in tissues and media from the spinal cord cultures bearing the familial ALS (fALS) mutation SOD1G93A (Davoli et al., 2015). Hydrogen sulphide (H2S) has been considered a physiological messenger alike the gasotransmitters nitric oxide and carbon monoxide as well as a novel neuromodulator exerting neuroprotective effects in the brain. Experimentally it is evident that the effect of H2S on the cellular homeostasis depends on its concentration. We propose H2S as a new/additional player in the mechanisms of non-cell-autonomous motor neuron death as a product of glial activation. Here we further discuss its potentials as a novel therapeutic target in ALS.

Key words: Hydrogen sulphide, Amyotrophic Lateral Sclerosis, neuroinflammation, cerebrospinal fluid.

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